فهرست مطالب

مجله علمی پزشکی جندی شاپور
سال چهارم شماره 4 (پیاپی 47، زمستان 1384)

100 صفحه، بهای روی جلد: 5,000ريال
تاریخ انتشار: 1385/03/11
تعداد عناوین: 10

فارسی
English

انتخاب همه

Comparison of Efficacy of Intranasal with Oral Anti-Staphylococcal Treatments in Control of Infection among Hospital MRSA Carriers

Alavi Sm, Rajabzadeh Ar, Dezfulian A., Haghighizadeh Mh, Naghibzadeh M Page 292

Objectives
Hospital nasal carriage, among health care staff, of methicillin resistant S. aureus (HNC-MRAS) have an important role in hospital-acquired infections (HAI) in admitted patients, which can lead to various complications such as wound infection, catheter related bacterimia, neonatal sepsis, with high mortality rates and socio-economic and health impacts. The aim of the present case-control clinical trial was to compare the efficacy of various anti-microbial treatments in the control of MRSA.
Methods
Seventy six HC-MRSA of the heath care staff who were positively identified as HC-MRSA in Razi hospital, an educational hospital of AJUMS, were randomly allocated into 5 groups. The first group was used as placebo-treated control. The remaining groups were treated for seven days twice daily with intra-nasal application of 2% mupirocin ointment, 2% vancomycin jell, or orally 500 mg cloxacillin QID plus daily 600 mg rifampicin or 2Tablet adult co-trimoxazol twice daily plus daily 600 mg rifampicin.
Results
The results showed that there was significant reduction in the MRSA following intranasal mupirocin ointment and voncomycin jell which eliminated 93% and 86% of nasal carriage respectively. Oral treatment (cloxacillin 500mg Q6h plus rifampicin 600 mg daily) or (co-trimoxazol 2 adult tablets Q12h plus 600 mg rifampicin daily) resulted in 100% elimination of nasal carriers in HNC- MRSA.
Conclusion
These results suggest that HNC-MRSA can be controlled with intranasal mupirocin or vancomycin. In cases that do not respond to topical treatment or due to drug hypersensitivity, cloxacillin plus rifampicin or co-trimoxazol plus rifampicin are recommended.

Abstract View Paper Original: Persian
A Study on the Prevalence of Transfusion Transmitted Virus by Seminested-PCR Among Patients With Thalassemia Major

Baba-Ahmadi.M., Zandieh T., Poor Fathalleh Aa, Galehdari.H., Assarzdegan M. A, Emam S.J. Jalali Far Ma, Zandian Kh Page 301

Objectives
Patients with thalassemia major are at increased risk of blood borne viral infections. TT virus (TTV) is a single stranded circular DNA virus which is involved in the development of post-transfusion non A– C hepatitis. The aim of the present investigation was to assess the prevalence of TTV infection among these patients.
Methods
Two hundred and fifty patients with thalassemia major were the subject of this study. TTV DNA was amplified from plasma by seminested polymerase chain reaction (PCR) with TTV–specific primers (NGO59, NGO61, NGO63) from the conserved regions in ORF1 (This segment consists of 271 bp). The data collected were compared with 250 blood samples taken from healthy blood donors in the central blood bank. Data were analysed using the 2 and Fisher’s exact test, as appropriate.
Results
The prevalence of TTV DNA was significantly higher in thalassemic patients (57.2%, 143/250) than in healthy controls (20%, 54/250). The prevalence of positive TTV DNA was found to increase with age and number of transfusions (p<0.01 and p<0.04 respectively). There is no statistically significant association between TTV DNA prevalence and the gender.
Conclusions
TTV is highly prevalent both among thalassemic patients living in Khouzestan province of Iran who undergo multiply transfused as well as in healthy blood donors. Based on these observations, it is likely that the parental route may not be the only mode of spread TTV. Okamoto et al. have previously shown that TTV DNA is present in faeces, which may further supports the faecal–oral route of viral transmission.

Abstract View Paper Original: Persian
Effectiveness of Massage on Intensity and Frequency of Headache in Women

Elahi N., Rahzani K., Jalali M., Haghighi M Page 306

Objectives
Tension headache is the most common type of headache. Tension headache is mostly caused by stress, anxiety and depression. The treatment of this type of headache is achieved by pharmacological and non-pharmacological methods. Drugs used in its treatment can predispose to over use, side effects and increased costs. The purpose of this study was to evaluate the effectiveness of massage in the treatment of chronic tension headache.
Methods
This research is semi-experimental study in which 25 women suffering from chronic tension headache were treated by massage during a 5-week period. During the intervention the subjects were massaged on their posterior parts of the neck and shoulders for 20 minutes twice a week and were asked to record their headache indexes four times a day on a checklist. Headache indexes included: intensity and frequency of headache and quantity of analgesics taken. Headache intensity was recorded by an 11-point criterion. The collected data from the second, third and fourth weeks of investigation were recorded as the data of ongoing intervention. While those collected from weeks 1 and 5 were considered as pre and post-treatment values.
Results
The headache indexes showed a meaningful difference in the three stages of per, during and post intervention (p<0.01). Consequently the recovery rates for each index was 52%, 39% and 57% respectively.
Conclusion
Massage therapy influences the intensity, frequency and quantity of analgesic intake in chronic tension headache and can cause faster recovery or reduce the intensity of tension headache.

Abstract View Paper Original: Persian
Allocation of the Best Day for Detection of the Dominant Follicle by Serial Sonography on Infertile Women on Comiphen Citrate

Zargar M., Razi T Page 318

Objectives
In order to reduce the number of sonography examinations, as well as costs and anxiety associated with this procedure, this study was conducted for allocation the best day for performing this procedure in order to identify the dominant follicle.
Methods
In this cross sectional descriptive study one handred infertile females received 100 mg clomiphen citrate from day 3 to 8 of the menstural cycle. The diameter of the dominant follicle as well as endometrial thickness were measured daily by serial sonography from day 12 to 15 of cycle.
Results
The diameter of the follicle in 70% of cases was 15 to 30 mm on day 13 of the menstrual period. The minimum measurement of endometrial thickness was on day 12 in 84% of the cases. While the maximum measurement was on day 15 in 67 % of cases. Thirty six percent of the patient did ovulate mainly on day 14 of menstural cycle. There was a positive correlation between the growth of the follicle with increase in endometrial thickness in 31% of patients, which was meaningful on day 14 of menstural cycle (p<0.05).
Conclusions
The findings from this suggest that the best day for prediction the probibility of ovulation by a single sonoraphy eximation is on day 13 of the cycle.

Abstract View Paper Original: Persian
Prevalence and Risk Factors of Microalbuminuria in Type 2 Diabetes Mellitus

Shahbazian Hb, Shahbazian H., Ahmadzadeh A., Latifi M Page 320

Objectives
Diabetic nephropathy is one of the most important late complications of diabetes mellitus (DM) which leads to a high rate of morbidity and mortality. In initial stages of diabetic nephropathy, there are some pathologic changes in kidneys and rising of GFR. After several years, microalbuminuria is usually present, which may progress to overt proteinuria and end stage renal disease. This study was designed to assess the prevalence of microalbuminuria in type 2 DM patients visited Razi Diabetes Center of Ahvaz Jundishapur University of Medical Sciences.
Material And Methods
A questionnaire included age, sex, time from diagnosis of DM, history of hypertension and hyperlipidemia were filled out for each patient. Laboratory studies include: serum level of BUN, Creatinine, Triglyceride, Cholesterol, 24 h urine collection for measurement of urine creatinine, volume, microalbumin, U/A and U/C were performed for each patient.
Results
Ninety out of 199 patients were men and 108 were women (age ranged between 36 to 60 years). 127 patients (63.7%) showed normal urinary microalbumin (less than 30mg/day), 70 patients (35.2%) microalbuminuria (microalbumin excretion between 30-300mg/day) and 2 patients (1.1%) macroalbuminuria (24 h urine microalbumin  300mg/day). 99 patients (43%) had hypertension (BP  140/90 mmHg). 121 patients (61%) had diagnosis of DM for less than five years, 29 (14.5%) between five and ten years and 24 patients (12%) more than 15 years. 41% of patients had familial history of diabetes mellitus and 40% had hyperlipidemia (Triglyceride >250 or Total cholesterol >200 or both). Hyperlididemia, higher age group of patients and longer duration of diagnosis of DM had significant effect on the level of microalbuminuria (p< 0.001, <0.001, <0.000 respectively).There were no significant differences between microablumuric and non-microalbuminuric patients, in level of BP and family history of DM.
Conclusions
Prevalence of microalbuminuria in the studied group is relatively high (35.2%). Furthermore, hyperlipidemia, older age and duration of DM are risk factors for developing microalbuminuria.

Abstract View Paper Original: Persian
An Anatomical Study on the Azygos Venous System

Safikhani Z., Kallantarmahdavi Srd Page 329

Objectives
The azygos venous system under the diaphragm at the superior part of posterior abdominal wall varies in its origin. Commonly, the azygos vein begins by the union of the ascending lumbar and subcostal veins on the right side. It passes through the aortic opening or posterior to the right crus of diaphragm enter the thorax and lying on the right side of the vertebral bodies, it ascends on the vertebral bodies and then arches over the root of the right lung to enter the superior vena cava. It receives the right lower eight posterior intercostal veins and at its convexity the superior intercostal veins join it. The hemiazygos is formed on the left in a manner similar to that of the azygos and receives the lower posterior 9th to 11th intercostal veins.The accessory hemiazygos receives the 5 to 8 intercostal veins, these two veins enter the azygos vein.The upper posterior intercostals veins forms the left superior intercostal vein which drains into the left brachiocephalic vein. The aim of the present study was order to investigate the variation of the azygos venous system in human cadavers.
Methods
For this purpose 10years of study was carried out on 40 male cadavers (with the proximate age of 40 to 80 years).
Results
In all cases the azygos vein lied on the right side of the vertebral column and also no bilateral azygos vein was observed. In the 5% of cases the hemiazygos was absent and the related intercostal veins drained directly into azygos. In 2.5% of the cases the accessory hemiazygos has not been formed and consequently the intercostal veins of 5 to 8 with a single trunk ran anterior to the vertebral column, then joined the azygos vein. Finally, in 25% of cases the hemiazygos and accessory hemiazygos communicated with each other and by a single channel at the level 8th vertebra enter the azygos vein.
Conclusions
The network of azygos venous system is corresponded to the general patterns reported in Gray’s Anatomy, however the azygos vein was not observed neither on the left nor in front of vertebral column and in one case the hemiazygos was absent. The knowledge of these variations will be important in study of radiographic, dissection and surgery of the posterior mediastinum.

Abstract View Paper Original: Persian
Evaluation of Echinococcus granulosus protoscolex antigen in human cystic echinococcosis detection using ELISA and Western Blotting

Rafiei A., Mirzaei A., Jahanshahi Ah, Talaeizadeh Ahand Maraghi S Page 331

Objectives
Serological diagnosis of cystic echinococcosis (CE), caused by Echinococcus granulosus, has been performed by different techniques. The lack of a standardised method for antigen preparation affects the sensitivity and specificity of the tests. The aim of this study was to assess the usefulness of Echinococcus granulosus protoscolex antigen, obtained from naturally infected sheep, using ELISA and immunoblot techniques.
Methods
Overall we tested 353 serum samples comprising: one hundred sera from surgically confirmed cystic echinococcosis, 200 sera from native healthy sheep and 53 heterologous sera were evaluated.
Results
ELISA results showed 86 of samples of hydatidosis sera were positive and 14 samples showed negative. While 14 samples of heterologous group showed cross reaction. The sensitivity and specificity of ELISA obtained 86% and 75.5% respectively. On the other hand, protoscolex of Echinococcus granulosus, after electerophoresis by SDS-PAGE, showed 13 antigenic bands of 28-112 KDa that reacted with serum samples. With immunoblot test, 93 samples of hydatidosis sera showed positive reaction with antigenic bands and 7 samples were negative. The 38 KDa band showed good immunoblot specificity and 59KDa antigen showed high sensitivity. Overall cystic echinococcosis diagnosis by immunoblotting indicated 93% and 64.1% sensitivity and specificity respectively.
Conclusions
The findings from the present study suggest that protoscolex can be considered as a good source of antigenic component in serological cystic Echinococcos granulosus. Furthermore, the use of the combination of ELISA and immunoblot techniques for confirmation of laboratory diagnosis of human echinococcosis is advantagous. In addiiton, 38 KDa antigen is the most specific fraction of protoscolex in immunological tests

Abstract View Paper Original: Persian
Formulation of Diphenhydramine mucoadhesive Paste and evaluation of it's Physicochemical Characteristics

Khazaeli P., Ajilchi H Page 341

Objectives
Aphthous stomatitis is one of the common mouth problems. Several medical procedures have been suggested for its treatment. Diphenhydramine has been commonly used to control aphthous pain because of its local anaesthetic effect. One of the important factors that determine its effectiveness in the treatment of aphthous ulcer is persistent at the location. Some of mucoadhesive drug formulations such as Adcortyl (containing corticosteroids)have several inherent side effects like candidiasis. The purpose of this research was to prepare a mucoadhesive formulation of diphenhydramine in a suitable base which can be used in the treatment of aphthous stomatitis.
Methods
In the first stage, low-density propylene glycol (LDPE) and liquid paraffin were used for preparing the plastibase by shock cooling method. This base was quality-tested and the suitable method to prepare the mucoadhesive base was determined. In the second stage of work, ten formulations containing different concentrations of gelatine, pectin, Na-CMC were prepared. The adhesive strengths, the occlusivity and the spreadability of the pastes were studied. The selected preparations were tested for drug release studies by Franz diffusion cell.
Results
The results showed that the selected formulation has the adhesive strengths equal to 109 mNcm-2 similar to the commercial product with a release drug flux rate of 6.7 g/cm2min.
Conclusions
These results showed that diphenhydramine can be formulated in a mucoadhesive base with proper mucoadherence, exclusivity, occlusivity spreadability with suitable release profile that makes it useful for use in aphthous stomatitis

Abstract View Paper Original: Persian

علمی مصوب

مجله علمی پزشکی جندی شاپور

Jundishapur Scientific Medical Journal

دوماهنامه پزشکی

آخرین شماره | آرشیو

ISSN: 2252-052x

صاحب امتیاز:

دانشگاه علوم پزشکی جندی شاپور اهواز

مدیر مسئول:

دکتر اسماعیل ایدنی

سردبیر:

دکتر عبدالحسن طلایی زاده

تلفن نشریه: ۰۶۱-۳۳۷۳۸۲۸۳

اطلاعات بیشتر نشریه

درباره نشریه پیام به نشریه سایت اختصاصی نشریه پذیرش الکترونیکی مقاله راهنمای نویسندگان

به جمع مشترکان مگیران بپیوندید!

فهرست مطالب

مجله علمی پزشکی جندی شاپور سال چهارم شماره 4 (پیاپی 47، زمستان 1384)

مجله علمی پزشکی جندی شاپور

Jundishapur Scientific Medical Journal

مجله علمی پزشکی جندی شاپور
سال چهارم شماره 4 (پیاپی 47، زمستان 1384)